Development of the Talamus bioreactor systems is carried out as a joint project of Pikolab Engineering and Pikolab R&D. At Pikolab, our work on bioreactor control systems goes back to the BioSIS recording and control system we introduced in 2013. The recording and control unit of Talamus laboratory systems is based on the BioSIS architecture.
At Pikolab Engineering, we have worked in process instrumentation and process analytical technology (PAT) since 2011. For Talamus systems, we carry out process engineering, mechanical design, fabrication, instrumentation integration, commissioning, sales and service.
info@pikolab.compat.pikolab.com
At Pikolab R&D, we develop process control, process analytics, automation and decision support software. The company was founded at Manisa Technopark in 2025, based on the field experience of Pikolab Engineering. We are responsible for developing the control and data layer of Talamus systems and the QorSense technology.
arge@pikolab.comarge.pikolab.comWe define the organism, product, target output, batch time and site utilities (steam, compressed air, cooling water, water, power, layout) together with you.
Output User requirements specification (URS)
We size the seed train, vessel volume, heat transfer, gas supply and agitation and prepare the Piping and Instrumentation Diagram (P&ID). We define phases, control loops, permissives, interlocks and the alarm approach in the Control Philosophy document.
Output P&ID, layout, instrument list, Control Philosophy
Product-contact surfaces are made from certified AISI 316L. We document design pressure, test method and acceptance criteria for vessel and jacket to the applicable project standard. We prepare the panel, software and instrumentation in parallel with fabrication.
Output Material certificates and test records
We run the system in the workshop before shipment and check valve sequences, phase transitions, alarms and sensor readings. Scope, acceptance criteria and customer attendance are defined in the contract.
We make the plant connections and calibrate the sensors. Within the Site Acceptance Test (SAT), we check plant connections, I/O, phases and alarms and carry out water runs. Where qualification is required, we define the design, installation and operational qualification (DQ/IQ/OQ) documents separately.
We prepare training content separately for operators, maintenance staff and process owners. It covers phase operation, set point management, calibration, alarm handling and basic troubleshooting.
We provide planned maintenance, sensor recalibration and field support through our teams in İzmir and Manisa.
| Topic | Evaluation criterion | On Talamus |
|---|---|---|
| Starting point | Design inputs | Organism, target product and plant utilities |
| Scale | Control and data architecture at pilot and production scale | Shared software and data architecture from laboratory scale up to 30,000 L; equipment and control settings defined per scale |
| Measurement chain | Responsibility for sensor calibration and fault tracking | We select, install and recalibrate the sensors; sensor condition monitoring and maintenance prioritisation are performed with QorSense |
| Software and data | Access to raw data without additional licences | Process data exported via USB flash drive or Ethernet; local data storage option |
| Plant integration | Design scope of steam, air and water connections | We design steam, air and water connections together with the layout in a project-specific P&ID |
| Change requests | Number of counterparts for mechanical and software changes | We handle mechanical, automation and software changes under one project plan and responsibility matrix; Pikolab Engineering is the contractual counterpart |
| Service | Location of field service | We provide field service and technical support in Turkish through our teams in İzmir and Manisa |
| Cost structure | Components included in the package | Modular design; we quote only the required components |
Our Google Scholar profile lists 16 studies; most are microalgae and cyanobacteria research run with airlift and flat-panel photobioreactors. 5 publications name the BioSIS controller explicitly in their methods section.
The methods section of these publications states explicitly that culture conditions were measured and controlled with the Pikolab BioSIS controller.
Studies listed on the Pikolab Engineering Google Scholar profile, run by the same research group with airlift and flat-panel photobioreactors. The equipment used is stated in the methods section of each publication.
Information on the project schedule, battery limits and FAT, SAT or qualification expectations is sufficient for an initial assessment.